�Investigators from the Melbourne Center of the outside Ludwig Institute for Cancer Research (LICR) and Pacific Edge Biotchnology Ltd today reported that they hold developed a test to predict whether a patient will progression rapidly from Stage III melanoma to metastatic Stage IV cancer and death.
More than 70% of patients with Stage III melanoma - melanoma that has spread to the lymph nodes - testament typically have a rapid time to progression (TTP) to Stage IV malignant melanoma, and put across away inside five old age of their diagnosis. However, the remaining
The LICR Melbourne squad, together with collaborators from Pacific Edge Biotechnology Limited in New Zealand, has developed a prototype test that can buoy distinguish 'tween these deuce patient subtypes with 85-90% accuracy. However, the team cautions that these findings must be validated in a bigger number of patients earlier the test can be applied routinely as a prognostic dick.
According to the senior author of the study, LICR's Professor Jonathan Cebon, M.D., the predictive test could assist patients and their health care teams in devising treatment decisions. Perhaps to the highest degree importantly, organism able to distinguish betwixt the subtypes could get a tremendous impact on the developing of new melanoma therapies. "One of the major problems we have in clinical trials for new melanoma therapies is that we can't identify the people wHO are going to own a slower disease advance no matter what they receive in a clinical trial," says Professor Cebon. "When new treatments are tested it is necessary to present clinical benefit by comparison patients world Health Organization receive the new therapy with those who do not. Although patients might all have the same type of cancers, at that place can be big differences in their survival simply because their cancers do differently - and this may make nothing to do with the intervention. If we are able-bodied to key out the good players and the bad players upfront, it becomes a whole lot easier figuring out whether good results are due to the new treatment or not. Most importantly far fewer patients would be needed for the clinical trials. It's partly because we can't clinically identify subtypes of patients that we suffer to do very big and very expensive trials. And, of course, this increases the time it takes to test the clinical benefit of potential drop new therapies."
The joint Australian/New Zealand team used microarrays to measure the expression of more than 30,000 genes in lymph knob sections taken from 29 patients with Stage III melanoma. There were 2,140 genes differentially expressed in the sections from people world Health Organization had already had a "poor" outcome (average TTP of just four months) and patients that had had a "good" outcome (average TTP of 40+ months). Using statistical analyses, the team identified 21 genes that could be used to differentiate between the deuce subtypes of patients in the retrospective analysis. This gene signature was then used to prospectively examine another 10 patients, with the clinical outcome for nine of the 10 (90%) patients proving to be predicted accurately. The one patient who was incorrectly predicted to have a "good" prognosis did have a rapid TTP to Stage IV. However, this patient role went on to feature a drawn-out survival of six years. The squad also applied the test to promulgated data sets and showed they could get a prediction truth of 85%, event though data was not uncommitted for all 21 genes in the published literature.
This discipline was conducted under the auspices of the Hilton - Ludwig Cancer Metastasis Initiative. It was light-emitting diode by investigators from: LICR Melbourne Center Austin Health, Melbourne, Australia; Department of Biochemistry, University of Otago, Otago, New Zealand; Pacific Edge Biotechnology Limited, Dunedin, New Zealand, and; Department of Statistics, University of Auckland, Auckland, New Zealand.
Source - Sarah L. White
Ludwig Institute for Cancer Research
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Friday, 29 August 2008
Tuesday, 19 August 2008
Heidi & Spencer to Marry on Live TV
If you think Heidi Montag and Spencer Pratt are slowing down their quest for world say-so, think again.
On Monday, Heidi confirmed in an question with Extra that she and Pratt plan to marry on live TV, saying, "I'm just waiting for that big ring!"
Montag also aforesaid that on that point could be little "Speidis" hamming it up for the cameras in the future (Can you imagine?).
"I want kids...eventually," she says. Over the weekend, The Hills co-star, Audrina Patridge, open up almost her frosty relationship with Montag, telltale, "You know, I don't have a problem with her...That's 'tween her and Lauren [Conrad]."
Heidi confirms there's no problem between herself and Audrina, saying, "We hang kO'd. We're friends...I love Audrina."
When asked if she had any plans to leave The Hills, Montag aforesaid, "No, where would I go?"
Well, at least she knows it!
Tune in to Extra tonight to see the full interview!
Would you watch Heidi and Spencer's wedding on live TV?
Sure, I love a good trainwreck!
Ugh, No! Enough with them already!
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Saturday, 9 August 2008
Int and The Movement
Artist: Int and The Movement
Genre(s):
Other
Discography:
Version 1.0
Year: 2004
Tracks: 4
Terri Clark
Tuesday, 1 July 2008
Dannii Minogue 'Unhappy' at Cheryl Cole's X Factor Pay Deal
Dannii Minogue is said to be "not happy" at new X Factor judge Cheryl Cole's �800,000 ($1.6m) pay packet -- because it's only �100,000 ($200k) less than hers.
Dannii, the sister of Kylie Minogue, feels there should be a bigger pay gap between the pair and she should be earning nearer former judge Sharon Osbourne's �1.5m ($3m) salary.
A source tells Britain's Daily Mirror newspaper, "She's not happy that Cheryl is on �800,000, just �100,000 less than her. She feels there should be a bigger gap and, with Sharon gone, she should be earning nearer her �1.5m pay packet."
And because of the age difference between the pair -- Chery's 24; and Dannii's 36 -- there's fierce competition between the two ladies to look the best -- and insiders reckon Dannii has had work done.
The source adds, "Dannii walked into Arsenal's Emirates stadium for the auditions and you could tell she'd put in a lot of work into looking good. She knows there's a younger, more successful, more attractive kid on the block and they will both be fighting for attention.
"Dannii's face seems a lot tighter than last year and everyone is gossiping that she's had a bit of work done.
"She's 36 and Cheryl is just 24 and she's desperate not to be cast as the older Sharon Osbourne type -- she wants to be Cheryl's equal. But it isn't working out like that."
And Dannii is also said to be feeling "eclipsed" by the Girls Aloud singer -- because she's constantly winning praise from Simon Cowell, who's calling her the 'new Cilla Black'.
"She has a great empathy for those auditioning because she has been there herself," the source adds.
"She has had a tough time and knows what it is like to go throught his process. Simon is delighted with how things have gone.
"He is calling her the 'new Cilla Black'. She has that touch that connects with people. She is a natural fit to the show and makes Dannii somewhat redundant.
"Louis and Cheryl get on like a house on fire as he managed Girls Aloud. He has never really got on with Dannii so that has made her feel even more isolated.
"It's ironic that last year Sharon felt under threat from the younger rival when Dannii arrived. Now it is Dannii who is under pressure herself."
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Monday, 30 June 2008
Shirley Bassey out of Nelson Mandela birthday concert
Dame Shirley Bassey has pulled out of the forthcoming Nelson Mandela tribute concert, set to take place at London's Hyde Park on Friday (June 27) to mark his 90th birthday.
Bassey had emergency stomach surgery last month, but was expected to recover in time for the performance. However, her surgeon has advised her not to travel, reports BBC News, prompting her cancellation.
Amy Winehouse is still scheduled to appear at the bash, despite being diagnosed as suffering from the lung disease emphysema.
Queen, Annie Lennox and Simple Minds are among the other acts set to play at the show.
Bassey had emergency stomach surgery last month, but was expected to recover in time for the performance. However, her surgeon has advised her not to travel, reports BBC News, prompting her cancellation.
Amy Winehouse is still scheduled to appear at the bash, despite being diagnosed as suffering from the lung disease emphysema.
Queen, Annie Lennox and Simple Minds are among the other acts set to play at the show.
John Coltrane with Johnny Hartman
Artist: John Coltrane with Johnny Hartman
Genre(s):
Pop
Discography:
John Coltrane and Johnny Hartman
Year: 1995
Tracks: 6
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